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KMID : 0613820100200040618
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Journal of Life Science
2010 Volume.20 No. 4 p.618 ~ p.622
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The Relationship between the Urinary Arsenic and 8-Hydroxydeoxyguanosine Levels in Women of Abandoned Mine Area
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Chou Young-Sook
Eom Sang-Yong
Choi Byung-Sun
Park Jung-Duck
Kim Yong-Dae
Kim Heon
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Abstract
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This study examines the relationship between urinary arsenic concentration and urinary 8-hydroxydeoxyguanosine (8-OHdG) concentrations, an index of oxidative DNA damage, among women who live near abandoned metal mines. The sample consisted of 165 residents living near two abandoned metal mines located in Chungbuk Province. Demographic characteristics as well as environmental factors relevant to arsenic exposure were collected through interviews, and urinary arsenic concentrations and urinary 8-OHdG concentrations of the research subjects were measured. The collected data were subsequently analyzed using the statistics program SPSS 12.0. The geometric average of urinary arsenic concentrations among the research subjects was 5.65 ㎍/g creatinine. In a correlation analysis between urinary arsenic and 8-OHdG concentrations, the correlation coefficient was significant (p＜0.001) at 0.399. This study suggests that urinary 8-OHdG concentrations may be a DNA damage marker for chronic arsenic exposure in women.
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KEYWORD
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Arsenics, 8-hydroxydeoxyguanosine, oxidative stress, abandoned mine
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